Down or Down's, Syndrome
- Down's syndrome, or Down syndrome, is a disorder caused by chromosome abnormalities that develop during germ-cell formation. If the affected ovum or sperm takes part in fertilization, the fetus will exhibit the syndrome. Characteristics include moderate to severe mental deficiency, slow physical development, stocky build, short hands, and flattened facial features.The syndrome was first described in 1866 by Dr. John Langdon Haydon Down (1828-1896), born in London and for many years a fellow of the Royal College of Physicians. The disorder had been called mongolism because of the Asian characteristics of eyes that appear to slant, but Down's name was later given to this disorder. In 1959 a French biologist, Jerome Lejeune, established that the production of a germ cell with an extra chromosome 21 is the most common cause of Down's syndrome.The possibility of this happening is more likely in the firstborn of an older mother, over forty years of age. Chromosome 21 is the smallest human chromosome, but its genes are of great importance not only in Down's syndrome but in cancer and Alzheimer's disease. People suffering from Down's syndrome may, with recent developments in medicine, live to about fifty years of age, but such individuals do not ordinarily become self-supporting. They are, nevertheless, often unusually sociable and affectionate.
Dictionary of eponyms. Morton S. Freeman. 2013.
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Down's Syndrome Scotland — Down syndrome Classification and external resources Scottish boy with Down syndrome assembling a bookcase ICD 10 Q90 … Wikipedia
Down's syndrome — Down syndrome a condition resulting from a chromosomal abnormality most commonly due to the presence of three copies of chromosome 21 (trisomy 21), which is most likely to occur with advanced maternal age. Down s syndrome can also occur as a… … The new mediacal dictionary
Down's syndrome — Down syndrome Down syn drome, Down s syndrome Down s syn drome, n. (Med.) A congenital disorder caused by an extra chromosome 21 in some or all cells. It causes a variable number and degree of abnormalities, including retarded growth, mental… … The Collaborative International Dictionary of English
Down's syndrome — ► NOUN Medicine ▪ a congenital disorder causing intellectual impairment and physical abnormalities. USAGE Down s syndrome is the accepted term in modern use, and former terms such as mongol and mongolism, which are likely to cause offence, should … English terms dictionary
Down's syndrome — Down s ,syndrome noun uncount DOWN SYNDROME … Usage of the words and phrases in modern English
Down's syndrome — Down s .syndrome n [U] [Date: 1900 2000; Origin: J. H. L. Down (1828 96), English doctor] a condition that someone is born with, that stops them from developing in a normal way, both mentally and physically … Dictionary of contemporary English
Down's Syndrome — 1961, from J.L.H. Down (1828 1896), English physician; chosen as a less racist name for the condition than earlier MONGOLISM (Cf. mongolism) … Etymology dictionary
Down's Syndrome Association — The Down s Syndrome Association (DSA) is a British charity which is the only organisation in this country focusing solely on all aspects of living successfully with Down s syndrome . The Association states its mission as: We provide… … Wikipedia
Down's syndrome — a condition resulting from a genetic abnormality in which an extra chromosome is present (there are three no. 21 chromosomes instead of the usual two), giving a total of 47 chromosomes rather than the normal 46. The chances of having a Down s… … Medical dictionary
Down's syndrome — N UNCOUNT Down s syndrome is a disorder that some people are born with. People who have Down s syndrome have a flat forehead and sloping eyes and lower than average intelligence. (in AM, usually use Down syndrome) … English dictionary